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κ-casein f(18-21) [id=CAK0005]

Producer Organism : Native Protein : Production Method :
Cow κ-casein Synthetic
Activity : Antibacterial
Target Organisms :

Gram-positive: Active against Staphylococcus aureus IFO 3060.

Gram-negative: Active against Escherichia coli IFO 3301, Salmonella typhimurium IFO 12529.

Description :
Production method: Synthetic.

Length : 4 Mass (Da): 494.57 Common Amino Acids : NSFK
Isolectric Point : 9.7 Net Charge : 1 Absent Amino Acids : ACDEGHILMPQRTVWY
Basic Residues : 1 Acidic Residues : 0 Hydrophobic Residues : 1
Polar Residues : 2 Boman Index : -12.61 Hydropathy Index : -1.35
Aliphatic Index : 0 Instability Index : 0 Extinction Coefficient :
Absorbance 280nm : 0

Wheel representation

Hydrophobicity plot

Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).
Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).
Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

Multiple Sequence Alignment (MSA)

1 CAKNATIVE 100.0%  FFSDKIAK 
2 CAK0003    75.0%  FFSN---- 
3 CAK0004    80.0%  FFSNK--- 
4 CAK0007    66.7%  --SNK--- 
5 CAK0005    75.0%  -FSNK--- 
6 CAK0006   100.0%  -FSDKIAK 

Citation: 1

Cytotoxic and antibacterial activities of chemically synthesized kappa-casecidin and its partial peptide fragments

Cited Entries: CAK0003, CAK0004, CAK0005, CAK0007

Authors:Matin, M.D.A., Otani, H.
Journal: Journal of Dairy Research 2002, 69(02).
Abstract: Milk is known to provide not only excellent nutrition but also protection against infection in mammalian neonates. Whey proteins, such as immunoglobulins, lactoferrin, lysozyme and lactoperoxidase, are well known antimicrobial components in milk. Håkansson et al. (1995) demonstrated that some multimeric human α-lactalbumin derivatives induced apoptosis in immature and tumour cells. Yoo et al. (1997) found that lactoferricin, which had been isolated from peptic lactoferrin as an antimicrobial peptide, induced apoptosis in tumour and immature mammalian cells. Apoptotic cell death is considered to be an important physiological function in the development and homeostasis of multicellular organisms and to be a highly controlled means of eliminating dangerous, damaged or unnecessary cells without causing tissue damage. Therefore, these findings suggest that whey proteins may have beneficial health effects by restricting specific cell population in the body.
Keywords: κ-Casein; synthetic peptide; cytotoxicity; antibacterial activity.

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