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PP3 f(113-135) [id=LAP0002]

Producer Organism : Native Protein : Production Method :
Camel PP3 Enzymatic hydrolysis and Purification with LC method/Synthetic
Activity : Not determined
Target Organisms :

Unavailable data

Description :
Production method: Trypsin hydrolysis and purification with LC method/Synthetic.

Length : 23 Mass (Da): 2 678.26 Common Amino Acids : PMSTVKLEF
Isolectric Point : 7.55 Net Charge : 1 Absent Amino Acids : CGIQWY
Basic Residues : 4 Acidic Residues : 3 Hydrophobic Residues : 7
Polar Residues : 5 Boman Index : -41.21 Hydropathy Index : -0.37
Aliphatic Index : 63.48 Instability Index : 0 Extinction Coefficient :
Absorbance 280nm : 0

Wheel representation

Hydrophobicity plot

Red solid plot : values according to the hydrophobicity scale of Kyte and Doolittle (reference paper).
Yellow dashed plot : Experimentally determined hydrophobicity scale for proteins at membrane interfaces(reference paper).
Green dotted-dashed plot : prediction of transmembrane helices (reference paper). In this scale (unlike the others), more negative values reflect greater hydrophobicity.

Citation: 1

Camel (camelus dromedarius) milk PP3: evidence for an insertion in the amino-terminal sequence of the camel milk whey protein

Cited Entries: LAP0002

Authors:Girardet, J.-M., Saulnier, F., Gaillard, J.-L., Ramet, J.-P., Humbert, G.
Journal: Biochemistry and Cell Biology 2000, 78.
Abstract: The camel (camelus dromedarius) milk proteose peptone 3 (PP3) was purified successively by size exclusion fast protein liquid chromatography and reversed phase high performance liquid chromatography and then characterized by amino acid residue composition determination and chemical microsequencing after CNBr or trypsin cleavages. In comparison with the previously reported structure of camel milk whey protein, the camel PP3 contains an insertion in the N-terminal region which has approximately 24 residues, whereas the remaining C-terminal regions of these two homologous proteins are essentially identical. The camel PP3 seems to contain a potential O-glycosylation site localized in this insertion and 2 or 3 phosphorylated serine residues. PP3 belongs to the glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) family and could therefore play an immunological role in the camel or its suckling young.

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